| What iCAPTURE Does
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iCAPTURE components
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The key components and technologies that
together make up the innovations of the iCAPTURE Centre are illustrated
in the Figure (below).
1. Cardiovascular and Pulmonary Registries
2. Molecular Phenotyping Core(1)
3. Ultrastructural Imaging Core(2)
4. Dynamic Cellular Imaging and Biophysics Core(3)
5. Organ Pathophysiology and Imaging Core(4)
6. Foundations of Excellence
7. Integration  |
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1. The Cardiovascular and
Pulmonary Registries
The Cardiovascular (Heart) and Pulmonary (Lung) Registries are unique,
computerized, multi-institutional databases. The registries include patient
demographics and heart or lung information, digitized images including
photographs and x-rays, and a bank of tissue and molecular materials for
the purposes of research, education and diagnosis. |
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2 The Molecular
Phenotyping Core(1)
DNA, RNA, and protein expression in human or animal
tissues and cells are measured and evaluated in single cells and tissues.
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3. Ultrastructural
Imaging Core(2)
The structural detail of tissues, cells and molecules
will be evaluated at a very high power (x100,000). Scanning-probe microscopes
will explore the three-dimensional surface of cells at a very high power
and can be used on living cells to unlock secrets within. |
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4. Dynamic
Cellular Imaging and Biophysics Core(3)
The technologies in this core will image molecules
within a cell and measure electrical activity at the same time. Fine cellular
detail and rapidly-occurring cellular events will be measured. |
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5. Organ Pathphysiology
and Imaging Core(4)
Organ structure and function will be assessed
in patients using the Computed Tomography(CT)and Magnetic Resonance Imaging(MRI)
facility located at the Vancouver Hospital site. |
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6. Foundations
of Excellence
The iCAPTURE Centre builds on the knowledge base
in heart, blood vessel, and lung diseases that currently exists in the
McDonald Research Laboratories and that has been built and perfected since
1977. It includes the preparation and evaluation of tissues, expression
and localization of proteins and genes, the manipulation of genes, tissue
culture of organs and cells, digital image capture and measurement, computer
networking, and database management. The techniques are supported by an
infrastructure that has worked well in the McDonald Research Laboratories
for over 20 years.
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7. Integration
The iCAPTURE Centre builds on the integration of
knowledge based in heart, blood vessel, and lung diseases that currently
exists in the McDonald Research Laboratories. This integration will be
supplemented via a powerful computer network, data storage, and database
system. The data will then be organized, analyzed and explained.
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Copyright © 2006, iCAPTURE.ca
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MRL iCAPTURE Centre
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