Bruce McManus is Professor, Department of Pathology and Laboratory Medicine, at the University of British Columbia. Since 2006, he has served as Director of the James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research located at St. Paul’s Hospital and as the Scientific Director of the Heart Centre at St. Paul’s Hospital – Providence Health Care. In September 2007, Dr. McManus was appointed as the inaugural Director of the recently launched Providence Heart + Lung Institute at St. Paul’s Hospital. In February of 2008, Dr. McManus successfully led the PRevention Of epidemic Organ Failure (PROOF) team to a $15 million funding award to establish a Centre for Excellence and Commercialization in Research (CECR), in the Networks of Centres of Excellence (NCE) program.
Dr. McManus served as the inaugural Scientific Director of the Institute of Circulatory and Respiratory Health, Canadian Institutes of Health Research, from December 2000 until April 2006. In this capacity, he led the development and implementation of a strategic research plan for Canada to address scientific questions related to cardiac, respiratory, vascular, brain (stroke), blood, sleep, and intensive care-related disorders and diseases.
Dr. McManus received BA and MD degrees at The University of Saskatchewan, an MSc in Applied Physiology from Pennsylvania State University, and PhD in Exercise Physiology and Biochemistry from the University of Toledo. He pursued post-doctoral fellowships in Environmental Physiology at the University of California - Santa Barbara and in Cardiovascular and Pulmonary Pathology at the National Heart, Lung, and Blood Institute in Bethesda, MD. Residency training at the Peter Bent Brigham Hospital - Harvard University in Internal Medicine and Pathology, was followed by specialization in Cardiovascular Pathology. Following 11 years as a faculty member at the University of Nebraska Medical Centre, including a sabbatical as John F. Fogarty Senior International Fellow at the Max Planck Institute for Biochemistry, Martinsried, Germany, Dr. McManus joined the Faculty of Medicine of the University of British Columbia as Department Head of Pathology and Laboratory Medicine in July 1993, a post he held until December, 2000. Dr. McManus is a Fellow of the Royal College of Physicians and Surgeons of Canada, the College of American Pathologists, the American College of Cardiology and the American College of Chest Physicians.
Dr. McManus’ investigative program is focused on mechanisms, consequences, detection and prevention of injury and repair involved in inflammatory diseases of the heart and blood vessels, with particular emphasis on enteroviral infections of the heart and transplant vascular disease. He works in an interdisciplinary setting on questions for which answers are critically enabled by computational sciences including biomarker discovery and validation, information acquisition, annotation, and use, and registry development to support heart and lung research. Dr. McManus has co-authored over 280 peer-reviewed publications, as well as many chapters. He is currently editing his fourth book. He has served as Councilor for the International Society for Heart Research and for the American Society for Investigative Pathology. He is past-president of the Society for Cardiovascular Pathology. He currently serves on the editorial board of several professional and scientific journals, and on many advisory committees and boards. He has long been committed to training and mentoring scientist trainees across a range of disciplines. He has convened many public and private sector partnerships in research.
Dr. McManus has been recognized for his scientific contributions by numerous institutions through visiting professorships and lectureships. He was co-recipient of the prestigious Max Planck Research Award with Dr. Reinhard Kandolf in 1991. He was elected to the Royal Society of Canada as a Fellow of the Academy of Sciences in 2002. He received a UBC Killam Research Prize- Senior Scientist Category, and was elected as Fellow of the International Academy of Cardiovascular Sciences in 2003. In 2005, he was elected as an inaugural Fellow of the Canadian Academy of Health Sciences. Recently, Dr. McManus received the 2006 BC Innovation Council’s Lieutenant Governor’s Technology Innovation Award.
Education / Training:
University of Saskatchewan BA Biology and Physical Education 1963-1967
Pennsylvania State University MSc Exercise Physiology 1967-1969
University of Toledo PhD Exercise Physiology and Biochemistry 1969-1972
University of Saskatchewan MD Medicine 1973-1977
Extra-Degree Training And Experience:
University of Saskatchewan, Saskatoon, SK, Canada; President of Students' Physical Education Association, 1966-67; Research Assistant in Child Growth and Development Study, 1966-67
Pennsylvania State University, State College, PA; Teaching Graduate Assistant, 1967-68
University of Toledo, Toledo, OH; Teaching and Research Graduate Assistant, 1968-71
University of California, Santa Barbara, CA, Institute of Environmental Stress; Postgraduate Research Physiologist, 1971-73
University of Saskatchewan, Saskatoon, SK, Canada, Medical Student, 1973-77; President of Student Medical Society, 1976-77; Saskatchewan Medical Association Joint Committee on Internship Training, 1976-77; Cardiology and Cardiovascular Pathology electives at University of California, San Diego, 1976
Harvard University, Peter Bent Brigham Hospital, Boston, MA, Clinical Fellow in Medicine, Medical House Officer, 1977-78; Clinical Fellow and Resident in Anatomic Pathology 1978-80; Cardiovascular Pathology elective, Children's Hospital Medical Center (Drs. Van Praagh), 1979
Somerville Hospital, Somerville, MA, Emergency Room Medical Casualty Officer, 1978-80
National Heart, Lung and Blood Institute, Bethesda, MD, Pathology Branch, Senior Staff Fellow, 1980-82
American University, Washington DC, Visiting Professor, College of Graduate Studies, Winter-Spring 1982
Max Plank Institute for Biochemistry, Martinsried, Germany, John F. Fogarty Senior Fellow, 1989-90
Cheung C, Luo H, Yanagawa B, Leong HS, Samarasekera D, Lai JC, Suarez A, Zhang J, McManus BM: Matrix metalloproteinases and tissue inhibitors of metalloproteinases in coxsackievirus-induced myocarditis. Cardiovasc Pathol 15:63-74, 2006.
Wong J, Zhang J, Gao G, Esfandiarei M, Si X, Wang Y, Yanagawa B, Suarez A, McManus BM, Luo H: Liposome-mediated transient transfection reduces cholesterol-dependent coxsackievirus infectivity. J Virol Methods 133:211-8, 2006.
Rahmani M, Wong BW, Ang L, Cheung CC, Carthy JM, Walinski H, McManus BM: Versican: Signaling to transcriptional control pathways. Can J Physiol Pharmacol 84:77-92, 2006.
Esfandiarei M, Suarez A, Amaral A, Si X, Rahmani M, Dedhar S, McManus BM. Novel role for integrin-linked kinase in modulation of coxsackievirus B3 replication and virus-induced cardiomyocyte injury. Circ Res 99:354-61, 2006.
Singal RK, Docking LM, Girling LG, Graham MR, Nickerson PW, McManus BM, Magil A, Walker EK-Y, Warrian RK, Cheang MS, Mutch WAC: Biologically variable bypass reduces enzymuria after deep hypothermic circulatory arrest. Ann Thorac Surg 82:1480-1488, 2006.
Webb J, Chandavimol M, Hamburger JN, Pate G, McManus BM, Krucoff M, Mancini J: Initial experience with a novel coronary rinsing and thrombectomy system: “Rinspiration”. J Invasive Cardiol 18:188-92, 2006.
Rahmani M, Cruz R, Granville DJ, McManus BM: Allograft vasculopathy versus atherosclerosis. Circ Res 99:801-815, 2006.
Chung AWY, Hsiang YN, Matzke LA, McManus BM, van Breemen C, Okon E: Reduced expression of vascular endothelial growth factor paralleled with the increased angiostatin expression resulting from the upregulated activities of matrix metalloproteinase-2 and -9 in human type 2 diabetic arterial vasculature. Circ Res 99: 140-148, 2006.
Wen R, Wu V, Dmitrienko S, Yu A, Balshaw R, McManus BM, Keown PA for the Biomarkers in Transplantation Team. Biomarkers in transplantation: Prospective, blinded measurement of predictive value for the flow cytometry crossmatch after negative antiglobulin crossmatch in kidney transplantation. Kidney Int. 70:1474-1481, 2006.
Si X, Wang Y, Wong J, Zhang J, McManus BM, Luo H. Dysregulation of the ubiquitin-proteasome system by curcumin suppresses coxsackievirus B3 replication. J Virol 81:3142-50, 2007.
Read JT, Rahmani M, Boroomand S, Allahverdian S, McManus BM, and Rennie PS. Androgen receptor regulation of the versican gene through an androgen response element in the proximal promoter. J Biol Chem, 282:31954-63, 2007.
Esfandiarei M, Boroomand S, Suarez A, Si X, Rahmani M, McManus BM. Coxsackievirus B3 activates nuclear factor kappa-B transcription factor via a phosphatidylinositol-3 kinase/protein kinase B-dependent pathway to improve host cell viability. Cell Microbiol, 9:2358-71, 2007.
Cheung P, Lim T, Yuan J, Zhang M, Chau D, McManus B, Yang D. Specific interaction of HeLa cell proteins with coxsackievirus B3 3'UTR: La autoantigen binds the 3' and 5'UTR independently of the poly(A) tail. Cell Microbiol 9:1705-15,2007.
Cheung CT, Deisher TA, Luo H, Yanagawa B, Bonigut S, Samra A, Zhao H, Walker EK, McManus BM. Neutralizing anti-4-1BBL treatment improves cardiac function in viral myocarditis. Lab Invest 87: 651-661, 2007.
Mutch WAC, Buchman TG, Girling LG, Walker EKY, McManus BM, Graham MR: Biologically variable ventilation improves gas exchange and respiratory mechanics in a model of severe bronchospasm. Crit Care Med 35:1749-1755, 2007.
Cohen Freue G, Hollander Z, Shen E, Zamar R, Balshaw R, Scherer A, McManus BM, Keown P, McMaster R, Ng R. MDQC: A new quality assessment method for microarrays based on quality control reports. Bioinformatics 23:3162-3163, 2007.
Cheung CT, Marchant D, Walker EKY, Luo H, Luo Z, Zhang J, Yanagawa B, Rahmani M, Cox J, Overall C, Senior R, McManus BM: Ablation of matrix metalloproteinase-9 in coxsackievirus-infected mice increases severity of myocarditis. Circulation 117:1574-1582, 2008.
Burgess BL, Naus KE, Chan JY, McManus BM, Wellington CL: Excess ABCG1 does not affect atherosclerosis in fat-fed apoE-/-mice. J Lipid Res 2008 (under revision).
Cohen Freue G, Bergman A, Ohlund L, Smith D, Elliot M, Hollander Z, Zamar R, Balshaw R, Ng R, McManus BM, Keown P, McMaster W. Statistical analysis of iTRAQ-MALDI-TOF/TOF platform validation on human plasma. Mol Cell Proteomics 2008 (under revision).
Froehlich KF, Graham R, Buchman TG, Girling LG, Scafetta N, West BJ, Walker EKY, McManus BM, Mutch WAC: Comparison of physiological noise versus white noise to
drive biologically variable ventilation in a model of acute respiratory distress syndrome. Can J Anesthes 2008 (under review).
Marchant D, Si X, Wu W, Luo Z, Abraham T, Petersen T, Spiller B, Hegele R, McManus BM: Differential usage of the DAF coreceptor governs coxsackievirus B3 cell tropism: a novel mechanism of pH-dependent virus entry. Am J Pathol 2008 (under review).
Selected Recent Chapters:
McManus BM, Allard M, Yanagawa B: Hemodynamics Disorders. Chapter 7. Rubin’s Pathology, 5th Edition: Rubin R, Strayer D (eds), Lippincott Williams & Wilkins, Philadelphia, PA, 2008, pp.229-252.
Esfandiarei M, Yanagawa B, McManus BM: Single Gene Disorders in Dilated Cardiomyopathy. Chapter 4. In: Cardiovascular Genetics and Genomics for the Cardiologist. Liew CC, Dzau V (eds), Blackwell Publishing, Oxford, UK, 2006, pp.55-82.
McManus BM, Lee, CH: Primary Tumours of the Heart. Chapter 69. Braunwald’s Heart Disease: A Textbook of Cardiovascular Medicine, 8th Edition. Elsevier, Philadelphia, PA, 2007, pp.1815-1827.
Marchant D, Si X, Luo H, McManus BM, Yang DC: The Impact of CVB3 Infection on Host Cell Biology. Current Topics in Microbiology and Immunology. Springer Publications, Heidelberg, Germany, 2006, pp. 177-198.
Moien-Afshari F, Choy J, McManus BM, Laher I: Immunosuppression in Promotion of Cardiac Allograft Vasculopathy. Ed. RR Watson and D. Larson (eds), Blackwell Publishers, Massachusetts, USA, 2007, pp.57-79.
Esfandiarei M, McManus BM: Pathogenesis of Myocarditis. Annual Review of Pathology: Mechanisms of Disease, Volume 3, 2008,pp.127-155.
Carthy J, Heine H, Mui A, McManus BM: The Pathology of Heart Allograft Rejection. Chapter 10. Chronic Allograft Failure: Natural History, Pathogenesis, Diagnosis, and Management. Landes BioScience, Austin, Tx, 2008 [Epub April 2008]
McManus BM, Luo H, Si X: The Signaling Duel between Virus and Host: Impact on Coxsackieviral Pathogenesis. Advances in Biochemistry in Health and Disease. Springer Publications, Montreal, 2008 (in press).
Lin D, Scherer A, Ng R, Balshaw R, Flynn S, Keown P, McMaster R, McManus BM: Biomarkers in Drug Development: A Handbook of Practice, Appliance, and Strategy. Chapter 7. Translating From Pre-Clinical Results to Clinical and Back. Clinical Validation and Biomarker Translation. John Wiley & Sons, Inc. (in press).
Walmsley H, Burgess M, Brinkman J, Hegele R, Wilson-McManus J, McManus BM: Biomarkers in Drug Development: A Handbook of Practice, Appliance, and Strategy. Chapter 10. Where Are We Heading/What Do We Really Need? Ethics of biomarkers: where are the borders of investigative research, informed consent and patient protection. John Wiley & Sons, Inc. (in press).
Burke A, Jendy, J,Jr, Lee C, McManus BM, Virmani R.Primary and Secondary Tumors of the Cardiovascular System In: Atlas of Cardiovascular Pathology for the Clinician, McManus BM (ed), Current Medicine, Philadelphia, PA, (in press).
McManus BM, Kandolf R, Lui P: Toxic, Infectious and Inflammatory Cardiomyopathies In: Atlas of Cardiovascular Pathology for the Clinician, McManus BM, (ed.), Current Medicine, Philadelphia, PA, (in press).